Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Clinical Practice Liaison
The Clinical Practice Liaison (CPL) plays a vital field-based role within Madrigal’s Medical Affairs team, focused on improving the standard of care for patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH/NASH/MASLD). The CPL will proactively engage healthcare professionals (HCPs) to provide guideline-based, non-promotional disease education on the identification, diagnosis, and management of MASH.
This role centers on empowering clinical practices to adopt evidence-based care pathways, integrate non-invasive diagnostic tools, enhance risk stratification, and collaborate in multidisciplinary care models. The CPL will also serve as a bridge between the medical community and internal Madrigal teams, providing strategic insights that help shape broader corporate understanding and direction.
Key Responsibilities
Scientific & Clinical Education
Deliver unbiased, evidence-based education on MASH/NASH to HCPs based on identified gaps in knowledge or clinical implementation.
Present current clinical practice guidelines and real-world data on diagnosis, risk stratification, and patient management.
Maintain deep understanding of non-invasive testing (NITs), treatment paradigms, and clinical protocols across the liver/metabolic spectrum.
Practice Engagement & Enablement
Engage with clinicians, practice managers, and office staff to support implementation of MASH care protocols.
Support the integration of guideline-based approaches into routine clinical workflows and align practices with payer and quality standards.
Respond to unsolicited clinical and drug-related inquiries in a scientifically accurate and compliant manner.
Cross-Functional Collaboration
Partner with internal Medical Affairs and Commercial colleagues to address clinical questions and ensure consistent field insights.
Contribute scientific expertise to speaker training programs, advisory boards, and internal stakeholder education.
Represent Madrigal at national and regional scientific meetings, supporting booth activities and engaging in peer-to-peer exchange.
Insight Gathering & Strategic Feedback
Capture and report actionable insights from clinical practices to inform corporate strategies and educational content development.
Monitor evolving clinical trends and barriers to care in MASH/NASH to support internal planning and market awareness.
Compliance & Professional Standards
Adhere strictly to all applicable company and regulatory policies, including FDA and industry guidelines for non-promotional medical engagements.
Ensure thorough documentation and accountability for all scientific interactions.
Qualifications & Skills
Required:
Advanced healthcare or life science degree (e.g., PA, NP, PharmD, or other clinically relevant background).
Minimum 5 years of direct patient care in gastroenterology, hepatology, endocrinology, or metabolic disease.
Clinical familiarity with NASH/MASH diagnostic tools, especially non-invasive testing and risk stratification methods.
Strong grasp of U.S. healthcare system operations, including practice workflows, billing/coding, and payer dynamics.
Excellent verbal and written communication skills; ability to distill complex science for various audiences.
Proficiency with Microsoft Office tools, CRM platforms, and virtual communication systems.
Willingness to travel 60–70% weekly, including weekends for scientific congresses.
Preferred:
Previous experience in the pharmaceutical or biotech industry in a medical affairs or MSL role.
Understanding of industry standards for compliant medical information exchange and field-based scientific roles.
Ideal Candidate Profile
The ideal CPL candidate is a dynamic communicator and clinician-educator with a passion for improving patient outcomes. They bring deep therapeutic area knowledge, a collaborative mindset, and the ability to adapt scientific insights to practical, clinical solutions. This role is best suited for individuals with initiative, independence, and a commitment to advancing real-world care for patients with MASH/NASH.
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $173,000 – $211,000 per year.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected].
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.
Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].